Plot: Adult twin siblings Milo and Maggie Dean haven't seen each other in ten years, since Milo moved from their upstate New York hometown to Los Angeles to become an actor, his career never haven taken off. Between the two, Milo, openly gay, is the screwed up one, he who admits to bouts of depression, while Maggie has a stable career as a dental hygienist, and has been married for two years to Lance, described as a handsome "Labrador retriever": outdoorsy, loyal and the nicest person in the world. While they have never had the best of relationships with their remarried mother who now lives in Sedona, Milo and Maggie were more connected to their father, who died when they were fourteen and who in many ways they resemble in personality. Milo and Maggie reconnect when Maggie receives a telephone call that Milo is in the hospital having tried to commit suicide, she who invites him to stay with her and Lance in his recovery. In their time together, they will have to deal with their largely unspoken dysfunction as siblings, it a big part of his depression, and the emotional issues that hide her own depressive nature.
Alternative Plot: Following many years of estrangement, twins Milo (Bill Hader) and Maggie (Kristen Wiig) have an unexpected reunion after a set of near-tragedies. The situation forces them to confront how their lives became so broken. For Maggie, it means examining why she's so unhappy in a marriage to a loving husband. For Milo, it means meeting with his first love to see if their romance can reignite. Eventually, they learn that living truthfully and accepting each other is the only way to move forward.
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