Plot: Sissy Hankshaw (Uma Thurman) is born with enormous thumbs that help her hitchhiking through the U.S. from a young age. She becomes a model in advertising, and her New York agent, "the Countess" (Sir John Hurt), sends her to his ranch in California to shoot a commercial, set against the background of mating whooping cranes. There, she befriends Bonanza Jellybean (Rain Phoenix), one of the cowgirls at the beauty ranch. The cowgirls take command of the ranch from the Countess and drug the cranes with peyote. The Police besiege the ranch.
Alternative Plot: A beautiful young woman with unusually big thumbs, Sissy Hankshaw (Uma Thurman) decides, fittingly enough, to become a hitchhiker. After finding work as a model for feminine products, Sissy goes to shoot an ad at the Rubber Rose, a ranch owned by the Countess (John Hurt), the company's flamboyant cross-dressing head. While at the ranch, Sissy meets numerous other eccentric characters, including an outgoing and rebellious cowgirl named Bonanza Jellybean (Rain Phoenix).
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