Plot: Man with the Screaming Brain is a story of greed, betrayal and revenge in a small Bulgarian town. William Cole, wealthy industrialist, winds up with part of his brain replaced by that of a Russian cab driver Yegor. The two couldn't be more different, but they share one thing - both were killed by the same woman. Brought back to life by a mad scientist, William and Yegor form an unlikely partnership to track down their common nemesis.
Alternative Plot: An executive (Bruce Campbell), his wife (Antoinette Byron) and their chauffeur become the subjects of a mad scientist's experimental transplant surgery.
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