Plot: Physicists Abby Yates and Erin Gilbert are authors of a research book which posits the existence of paranormal phenomena, such as ghosts. While Abby continued to study the paranormal at a technical college with eccentric engineer Jillian Holtzmann, Erin, now a professor at Columbia University, disowned the work, fearing it will impact her tenure. When Abby republishes the book, Erin convinces her to agree to remove the book from publication in exchange by helping Abby and Jillian in a paranormal investigation. They witness a malevolent ghost, restoring Erin's belief in the paranormal, but video footage of the investigation is posted online, and Erin is fired by the university. She joins Abby and Jillian to set up new offices above a Chinese restaurant, calling themselves "Conductors of the Metaphysical Examination". They build equipment to study and capture ghosts, and hire the dimwitted but handsome Kevin Beckman as a receptionist..
Alternative Plot: Paranormal researcher Abby Yates (Melissa McCarthy) and physicist Erin Gilbert are trying to prove that ghosts exist in modern society. When strange apparitions appear in Manhattan, Gilbert and Yates turn to engineer Jillian Holtzmann for help. Also joining the team is Patty Tolan, a lifelong New Yorker who knows the city inside and out. Armed with proton packs and plenty of attitude, the four women prepare for an epic battle as more than 1,000 mischievous ghouls descend on Times Square.
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