Plot: Will Graham (Edward Norton) is an F.B.I. Agent who has an ability to get into the minds of criminals. Currently, he is pursuing someone who, in addition to killing people, is taking parts of their body. Initially, it is believed that he is collecting them, but Graham believes that he is actually eating them. So he goes to Dr. Hannibal Lecter (Sir Anthony Hopkins), a forensic psychiatrist, with whom he consults. When Lecter leaves him for moment, he discovers that Lecter is the man. Lecter then tries to kill him, but Graham manages to subdue him. Both men are hospitalized, and when they recover, Graham testifies against Lecter, and Lecter is convicted. Graham leaves the F.B.I. A few years later, Graham is approached by his former boss (Harvey Keitel) who wants him to help him find this guy who kills a family every full moon. Graham, who is still emotionally and psychologically scarred, reluctantly agrees. When Graham hits a wall, he goes to Lecter for help, and Lecter wants to play games with him.
Alternative Plot: Ex-FBI agent Will Graham (Edward Norton) is an expert investigator who quit the Bureau after almost losing his life in the process of capturing the elusive Dr. Lecter (Anthony Hopkins). After a series of particularly grisly murders, Graham soon realizes that the best way to catch this killer, known as the Tooth Fairy, is to find a way to get inside the killer's mind. For Graham, that means confronting his past and facing his former nemesis, the now-incarcerated Lecter.
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