Plot: Sergeant Sajan Chaudhri is instructed to take over the Police Station in a small town in Kanati District in India. His predecessor has been missing for over two months now. Sajan gets the feel of the town and it's people. Then one day two Caucasians, one a male, John, and female, Gina, attend the Police Station, asking for his assistance as one of their friends, Geraldine, has been bitten by a Bolivian spider and is being looked after by Dr. Lecorpus. They want his assistance in taking Geraldine to a proper medical facility. Sajan takes his jeep and goes to investigate. After alighting from the jeep, he is captured and brought into a primitive spider-worshiping village, and meets with Dr. Lecorpus. He is set free and upon inquiring about Geraldine, he is told that her health had improved and she decided to leave. Sajan decides to investigate further without realizing that he, along with John, Gina, as well as Brian, a Tourist Guide, and a woman named Stacey, will soon not only be the target of hordes of venomous spiders but also must run for their lives from a masked man who wants to paralyze them using spiders' venom, then take their organs out and sell them to the highest bidder.
Alternative Plot: In India, backpackers encounter a sinister scientist (Lance Henriksen) who lives with villagers who worship deadly arachnids.
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