Plot: A young man named Sean Jones witnesses vicious, powerful mobster Eddie Kim brutally murder a prosecutor bent on putting the crime mogul behind bars. Soon Kim's men raid Jones' house and attempt to kill him, but are stopped by Neville Flynn: an experienced FBI agent who convinces Jones to fly to LA to testify against Kim. Aboard the flight are an obnoxious British businessman, a famous hip-hop star, an anxious man with severe flight anxiety and his wife, a young woman and her dog, and a ticking crate full of vicious, venomous snakes unleashed by an assassin to bring down the plane along with the witness to Kim's brutal murder. Can the passengers come together to survive or will Kim's plot succeed?
Alternative Plot: FBI agent Nelville Flynn (Samuel L. Jackson) boards a flight from Hawaii to Los Angeles, escorting a witness to trial. An on-board assassin releases a crate of deadly serpents in an attempt to kill the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.
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