Plot: A group of research scientists, working in an abandoned off-shore submarine facility, appear to have discovered a neuro-stimulant, extracted from the brains of sharks, that cures Alzheimer's disease. However, unknown to the rest of the researchers the project leaders Dr. Susan McAlester and Jim Whitlock have illegally used proscribed gene manipulation techniques to enhance the brain size of the sharks to attain their spectacular results. During a severe storm, whilst the researchers are celebrating their success, the newly intelligent sharks attack their captors in a bid to escape. As a result of the storm and the sharks attack strategy, the research facility suffers a catastrophic structural integrity failure and begins to submerge. The situation becomes a deadly race against time as the survivors, led by shark wrangler Carter Blake and Preacher, try to reach the surface and safety as the deadly intelligent killer-sharks continue to flood the facility and hunt their prey.
Alternative Plot: On an island research facility, Dr. Susan McAlester (Saffron Burrows) is harvesting the brain tissue of DNA-altered sharks as a possible cure for Alzheimer's disease. When the facility's backers send an executive (Samuel L. Jackson) to investigate the experiments, a routine procedure goes awry and a shark starts attacking the researchers. Now, with sharks outnumbering their human captors, McAlester and her team must figure out a way to stop them from escaping to the ocean and breeding.
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